ABSTRACT
The purpose of this study is to compare the analgesic effect of drugs belonging to different chemical classes. It was observed that the analgesic effect is more rapid and persists for longer duration of action in normal as compared to diabetic animals
Subject(s)
Animals, Laboratory , Cyclooxygenase 2 , Hyperglycemia/drug therapy , gamma-Aminobutyric Acid , Mice, Inbred BALB C , Antidepressive Agents, Tricyclic , Anti-Inflammatory Agents, Non-Steroidal , Mice, Inbred NOD , Diabetes Mellitus/veterinaryABSTRACT
Opioid dependence is one of the major social and psychiatric problem of society. Unfortunately there is no non-opiate treatment available. This study was conducted to find out the role of Nigella Sativa as a potential non-opiate treatment for opiate withdrawal. The study was conducted at the Department of Pharmacology, University of Karachi and Drug Rehabilitation Centre, R.H.C., Murad Memon Goth, Karachi. The study was based on DSM IV criteria for opioid dependence. Nigella Sativa 250 mg is found effective in long-term management of opioid dependence
ABSTRACT
The neuropharmacologic profile of harmala alkaloids has been studied and found to have central effects like convulsions, catalepsy, or altered startle response. In number of studies the effects of diazepam, on harmaline and other beta carboline containing compounds-induced tremors were investigated. The present study was undertaken to examine the effect of diazepam on pretreated animals with harmaline and its synthesized phenacyl and coumarine analogues. Diazepam successfully inhibited the tremor and convulsions and attenuated the other behavioural response produced by Harmaline and its derivatives